Protein Details: Aquaporin-0n

Protein ID

ICDB_Pro_0473

Protein Name

Aquaporin-0n

Gene Name

MIP; AQP0

Organism

Homo sapiens (Human)

Length

263 amino acids

AlphaFoldDB

AF-P30301-F1-model_v4.pdb

Function

Water channel . Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling .

Sequence

MWELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLVQSVGHISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTGAGMNPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSISERLSVLKGAKPDVSNGQPEVTGEPVELNTQAL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 149: "Important for water channel gating"; SITE 246: "Interaction with BFSP1"; SITE 250: "interaction with BFSP1";

Disease

Cataract 15;Multiple Types and Persistent Hyperplastic Primary Vitreous

Location

Expressed in the cortex and nucleus of the retina lens (at protein level) (PubMed:30790544). Major component of lens fiber gap junctions (PubMed:24120416).

DOI ID

10.1016/0888-7543(91)90023-8; 10.1038/nature04569; 10.1101/gr.2596504; 10.1038/75538; 10.1016/j.ajo.2005.11.008; 10.1016/j.bbamem.2016.06.026; 10.1016/j.exer.2019.02.001; 10.1093/oxfordjournals.hmg.a018925; 10.1016/j.exer.2012.10.010; 10.1016/j.exer.2013.09.019; 10.1371/journal.pone.0126679; 10.1534/g3.117.300109; 10.1186/s13023-018-0828-0

RefSeq

NP_036196.1;